Why is gut health linked to immunity?

Written by
Stella Nilsson
Reviewed by
Prof. Benjamin Murphy, Ph.D.Most of your immune system lives in your gut. Therefore, healthy intestines are crucial for maintaining a robust immune system. A special tissue called gut-associated lymphoid tissue (GALT) is home to approximately 70% of the immune cells. These immune cells are constantly monitoring for the entry of pathogens through food and air. A healthy gut lining prevents damaging compounds from leaking into your bloodstream, thereby reducing the risk of inflammatory conditions.
Probiotic Defense
- Beneficial bacteria crowd out pathogens
- Stimulate secretory IgA antibody production
- Enhance tight junction proteins sealing gut lining
Prebiotic Fuel
- Fiber fermentation produces butyrate
- This SCFA reduces intestinal inflammation
- Fuels colonocyte cells maintaining barrier integrity
Probiotics interact directly with immune cells through the use of pattern recognition receptors. Beneficial strains, such as Lactobacillus casei, increase the regulatory T-cells that prevent autoimmune reactions. I have seen patients significantly reduce their allergy symptoms by consuming probiotic foods on a daily basis. Fermented vegetables provide diverse strains of bacteria that pharmaceutical probiotics often lack.
Prebiotic fibers undergo fermentation, resulting in the production of short-chain fatty acids (SCFAs). The short-chain fatty acid butyrate reduces inflammation by inhibiting NF-κB pathways. In contrast, the short-chain fatty acid acetate encourages antibody formation. Cook garlic and onions lightly to preserve inulin activity. This prebiotic fiber selectively feeds Bifidobacterium species, which are crucial for maintaining a robust immune system.
The integrity of the gut lining prevents 'leaky gut syndrome' where toxins get into the bloodstream. Glutamine in the bone broth repairs the tight junctions between the intestines. Zinc from shellfish helps maintain the strength of the mucosal barrier. Avoid NSAIDs and excess alcohol, which will impair this important barrier. Healing the gut lining often helps resolve chronic inflammation.
Read the full article: 10 Immune System Boosters for Better Health