What are the safety concerns with borage oil?

Published: October 20, 2025
Updated: October 20, 2025

There are specific safety concerns associated with borage oil; these require a discerning mind. The possible toxicity of borage oil is primarily because of pyrrolizidine alkaloids that may be present in borage oil products that were improperly prepared. Neurological hazards due to neurological involvement and drug interactions also require consideration. A knowledge of these matters will enable you to use this supplement wisely.

Liver toxicity is the most significant risk associated with non-PA-free borage oil, as the pyrrolizidine alkaloids cause cumulative damage to hepatic cells over time. Symptoms include jaundice, dark urine, and abdominal pain. Always use PA-free certified products to eliminate this risk.

Neurological Risks

  • Lowers seizure threshold in epilepsy patients
  • May trigger migraines or dizziness
  • Avoid with history of stroke or neural disorders
  • Discontinue if tremors or confusion occur

Drug Interactions

  • Increases bleeding risk with blood thinners
  • Reduces efficacy of immunosuppressants
  • Potentiates sedative medications
  • Alters metabolism of chemotherapy drugs

Gastrointestinal Issues

  • Causes nausea or diarrhea in 15% of users
  • May trigger acid reflux symptoms
  • Start with low doses to minimize effects
  • Take with meals to reduce discomfort
Risk Management Strategies
Risk Type
Liver Toxicity
PrecautionUse PA-free certified products onlyMonitoringLiver enzyme tests every 6 months
Risk Type
Neurological
PrecautionAvoid with seizure historyMonitoringNeurological exams if symptoms appear
Risk Type
Bleeding Risk
PrecautionDiscontinue 2 weeks pre-surgeryMonitoringRegular INR checks if on blood thinners
Risk Type
GI Distress
PrecautionStart with 500mg, increase graduallyMonitoringSymptom diary for first 4 weeks

Certain populations are at increased risk. Pregnant women should avoid borage oil, as it can induce labor. Children under the age of 12 should only take this under the supervision of a pediatrician. Those with liver problems should never take this. Always inform your doctor if you are taking supplements before starting treatment.

Proper use limits complications. The continuous use of these products should not exceed 12 weeks; after this period, a rest period is advised. There should be no use of larger amounts than 4000mg daily under any circumstance without medical supervision. Oils should be stored in dark containers and kept away from heat sources. Any reactions should be reported to the medical profession at once.

Read the full article: Borage Oil Benefits for Skin and Wellness

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