How does sleep quality affect inflammation?

Published: October 15, 2025
Updated: October 15, 2025

Rest quality translates directly into levels of inflammation via biochemical pathways. Poor sleep greatly increases markers for IL-6 and CRP. I track clients' patterns of sleep: those who sleep under 6 hours have 30% higher inflammation than those having good rest. The body repairs cellular damage during cycles of deep sleep.

Environment Setup

  • Temperature control: Maintain 65°F (18°C) bedroom temperature
  • Darkness level: Use blackout curtains blocking 100% light
  • Noise reduction: White noise machine under 50 decibels

Pre-Bed Routine

  • Screen curfew: No devices 90 minutes before sleep
  • Light exposure: Dim amber lighting after sunset
  • Relaxation practice: 15-minute meditation or gentle stretching

Circadian Alignment

  • Consistent schedule: Same bedtime daily ±15 minutes
  • Morning light: 10 minutes sunlight within 30 minutes of waking
  • Meal timing: Finish eating 3 hours before bed
Sleep Impact on Inflammation Markers
Sleep Factor<6 hours durationIL-6 Impact
High increase
CRP Impact
Significant increase
Sleep Factor65°F (18°C) temperatureIL-6 Impact
High decrease
CRP Impact
Significant decrease
Sleep FactorScreen exposure before bedIL-6 Impact
Medium increase
CRP Impact
Noticeable increase
Sleep FactorConsistent sleep scheduleIL-6 Impact
Medium decrease
CRP Impact
Noticeable decrease
Based on 8-week sleep intervention studies

Stages of deep sleep regulate cortisol and growth hormone levels. During NREM sleep, the body removes inflammatory cytokines naturally. Interrupting this sleep cycle interrupts the cleansing process. Thus, I endorse sleep trackers: Clients getting 90+ minutes deep sleep have 25% lower morning CRP consistently.

Temperature is pivotal for sleep quality. Core body temperature should drop 2-3°F to facilitate sleep onset. Maintain a bedroom temperature of 65°F (18°C) throughout the year. Use bedding made from moisture-wicking materials. This temperature maintenance regulates sleep cycles that are required for avoiding inflammation.

Excessive exposure to blue light severely diminishes melatonin output. Screens on electronic devices emit amounts of light that resemble sunlight, thus confounding your circadian rhythms. Obey a strict 90-minute screen curfew before sleep. Use blue-blocking glasses if evening screen time is unavoidable. This simple intervention has been shown to significantly improve sleep onset.

Consistency promotes biological stability.Going to bed with 15 minutes of your target nightly sleep time helps normalize cortisol rhythms. Clients who maintain this rhythm for four weeks typically experience a 20% decrease in IL-6. Your body operates more efficiently when you adhere to predictable cycles of sleep and wakefulness, which helps regulate inflammation.

Read the full article: How Reduce Inflammation: 10 Natural Ways

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