How does exercise influence inflammation in the body?

Published: October 15, 2025
Updated: October 15, 2025

Exercise plays a direct influence on your body's inflammation pathways in really big ways. Moderate physical exercise produces reductions in inflammatory markers (CRP and TNF-alpha) that are measurable. I take measurements of these changes with my clients: Regular movement produces measurable biological changes. Exercise increases anti-inflammatory myokines that reduce cellular damage.

Aerobic Training

  • Frequency: 5 sessions weekly at moderate intensity
  • Duration: 30+ minutes per session
  • Best options: Brisk walking, cycling, swimming

Strength Work

  • Frequency: 2-3 sessions weekly
  • Focus: Compound movements like squats and rows
  • Rep range: 8-12 reps using 70% max capacity

Recovery Essentials

  • Post-workout: 10 minutes stretching
  • Hydration: 16 oz water per hour of activity
  • Rest days: 1-2 weekly for inflammation regulation
Exercise Impact on Inflammation Markers
Activity TypeModerate AerobicCRP Reduction
High
TNF-alpha Change
Significant decrease
Activity TypeStrength TrainingCRP Reduction
Medium
TNF-alpha Change
Moderate decrease
Activity TypeHigh-Intensity IntervalCRP Reduction
Low
TNF-alpha Change
Temporary increase
Activity TypeLow-Impact (Swimming)CRP Reduction
High
TNF-alpha Change
Significant decrease
Based on 12-week intervention studies

Intensity matters greatly when it comes to controlling inflammation in the body. Moderate exercise lowers inflammatory markers, but intense training temporarily increases them. Maintain training heart rates at 60-70% of maximum. This sweet spot can cause the necessary anti-inflammatory response in the body without exceeding oxidative stress levels.

Mild exercises yield excellent results for joint swelling. Swimming and cycling decrease the trauma delivered to the knees and hips. Exercising in water builds resistance without the impact of land-based exercises. I suggest aqua-fit three times a week for individuals with arthritis. They invariably report a 40% reduction in their stiffness.

Recovery periods let your body leverage the maximum anti-inflammatory effect. During periods of rest, muscles release protective substances called myokines, spacing workouts out with 48 hours of separation from strength sessions. Active recovery, such as walking, can support healthy circulation without provoking the inflammatory process.

Regular exercise leads to a cumulative reduction of inflammation. Clients who exercised for 150 minutes per week had a 30% reduction in CRP over 8 weeks. Did you miss your workouts? Then start up again, even if not at an increased intensity level. Your body appreciates regular, moderate work best, and sporadic, intense work second best.

Read the full article: How Reduce Inflammation: 10 Natural Ways

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